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Wang and colleagues show that 4CL medium and MYCN/BCL2 overexpression generate human iPSCs with superior interspecies chimeric potential in pig embryos. This led to the successful formation of a humanized mesonephros in nephric-defective pig embryos via early embryo complementation, paving the way for growing a human kidney in pigs.
논문출처 : Cell Stem Cell, Wang, Xie, Li, Li, and Zhang et al. ‘Generation of a Humanized Mesonephros in Pigs from Induced Pluripotent Stem Cells via Embryo
기사출처 : The ScienceTimes
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